"The current methods for amide formation are remarkably general but at the same time widely regarded as expensive and inelegant. Not surprisingly, in 2007 the American Chemical Society Green Chemistry Institute (comprising members from major pharmaceutical industries worldwide) voted ‘amide formation avoiding poor atom economy  reagents’ as the top challenge for organic chemistry. Furthermore, even the best stoichiometric reagents often fail for the synthesis of sterically hindered amides . The issues of waste and expense associated with amide formation are compounded when applied to peptide synthesis, and are responsible for the great cost of commercial therapeutic peptides. The chemical synthesis of proteins is largely prohibited by limitations inherent to traditional amide formation..."(Footnotes are added by me and are located at the bottom of this article.)
In the nylon rope trick, the diacid is modified to form a diacyl chloride which then reacts with the diamine, in the process forming HCl. Fortunately, most commercial nylons are made from the straight diacid, or more correctly, the nylon copolymers such as nylon 6,6 are made this way. The diacid and the diamine form a isolatable, non-reactive salt which is then reacted at high temperature and pressure to induce polymerization. The nylon homopolymers, such as nylon 6, are made through a ring-opening polymerization of cyclic lactams. Most other organic compounds cannot tolerate the conditions or have an appropriate lactam, and so the search is ongoing for more and better techniques to create amides. Maybe some of these results will spill over into the polymer area, but I have my doubts. Just looking at some of the options
 "Poor atom economy" refers to the molecular weight of the product divided by the molecular weight of all the reactants. It is a trendy way to quantify the efficiency of a reaction. I'll have quite a bit more to say about it tomorrow.
 All easy reactions fail for sterically hindered products. While polymaleic acid has been made, 2-olefins in general are still considered to be very difficult to polymerize.